The definition of segregated schools implies that the institution separates members of a marginalized minority (such as ethnic minorities or learners with an immigrant background) from others. Levels of early school leaving is often higher in segregated institutions. This is due to the fact that students coming from marginalized communities face the same social disadvantages. The concentration of disadvantages in a certain classroom hinders learning opportunities and learning outcomes of the stigmatized students. Evidence shows that there is a strong link between early school leaving, social disadvantage and a low level of parental education, low socio-economic status being one of the key factors increasing the risk of early dropping out. A systematic response, developing effective strategies and policies for school de-segregation is thus a necessity if we wish to prevent early school leaving.